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CD22 antibody [2D6] (Low endotoxin, azide free)

Cat. No. GTX17558-00

Reference 4

Host

 Rat

Clonality

 Monoclonal

Clone Name

 2D6

Isotype

 IgG1

Application

 ICC/IF, IHC-P, IHC-Fr, FACS, IP, Activation

Reactivity

 Mouse
Package
500 μg ($479)
See all CD22 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Activation Assay dependent
Not tested in other applications.

Calculated MW

97 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

Purification

Purified IgG1

Endotoxin

< 0.05 EU/弮g (determined by the LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD22 antigen , A530093D23 , Lyb-8 , Lyb8

Cellular Localization

Cell membrane; Single-pass type I membrane protein

Background

Enables CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Database

Research Area

REFERENCE

Clone Reference

J Yuan et al. PLoS One 2013; 8 (5):e64572 A Novel Epitope from CD22 Regulates Th1 and Th17 Cell Function in Systemic Lupus Erythematosus
Application : FACS
JA Walker et al. Immunology 2008; 124 (3):412-8 Dependence of surface monoclonal antibody binding on dynamic changes in FccRIIb expression
Application : FACS
K Horikawa et al. J Exp Med 2007; 204 (4):759-69 Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
Application : IP
VW Chan et al. Curr Biol 1998; 8 (10):545-53 Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
Application : Activation
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Package List Price ($)
$ 479